My biggest regret is that gerontologists have been focusing so much money on a very, very few approaches to anti-aging research, says Dr. Sinclair, who urges people to explore lifestyle choices that have been proven effective in prolonging life. However, in mid 2021 he mentioned that he was experimenting with adding Fisetin and Quercetin (see this clip). Keeping it in the fridge, especially once opened, may result in moisture accruing within the container. Capsulating the PowdersWith the bulk powder versions of NMN above, you could put them into capsules yourself at home, using a capsule filling machine. Here's his current anti-aging regimen as outlined by Dr Hall: He makes no recommendations for others except "Eat fewer calories", "Don't sweat the small stuff", and "Exercise". Cool, isn't it? Stopped eating deserts at age 40, except for a small taste occasionally, Weight lifting now 3 times per week, was previously just 1 time per week. If you have found Dr. David Sinclair' tips valuable, you will just devour his book: "Lifespan: Why We Ageand Why We Don't Have To". You can read up on David Sinclairs Supplement Regime here. Studies have pointed to benefits such as: Whilst Davids resveratrol comes from excess product leftover from lab experiments, not all of us have this luxury! When to avoid Fruit juice and dried fruits Healthiest fruits Takeaway Fruit does contain some sugar, but it's still a healthy option. More recently, in 2019, Austrian researchers published the results of a double blind study in 79 older adults (~80 years) looking at the effect of spermidine supplementation on cognitive performance17The positive effect of spermidine in older adults suffering from dementia Pekar et al. He exercises in order to stay healthy and mentally sharp, rather than to be muscular, He doesnt smoke, avoids microwaved plastic, excessive sun exposure, X-rays, and CT scans, Aims to keep his BMI in the optimal range for healthspan, which for him he says is 23 to 25, Tries to stay on the cool side during the day, and at night when sleeping, Reduced inflammation and oxidative stress in healthy people, Improvements in memory tasks for obese, but otherwise healthy 50-75 year olds, Improvements in metabolic and cardiovascular markers, in people with obesity. The secret, Sinclair says, is something he calls "health span." The first is third party testing on the purity of their NMN. Bravo seems like a fairly expensive product to me, however, once nice trick with yogurts is that you can make a new batch using a small amount from the old batch. Based on multiple, recent interviews and his book, Dr. Sinclair's supplement and longevity drug stack likely looks as follows: Nicotinamide mononucleotide (NMN ): 1g per day, in the morning Resveratrol: 1g per day, in the morning Metformin: 800 mg, in the evening Vitamin D3: ideally 4,000 to 5,000 IU per day Specifically, they cause the cell to think its in a nutrient restricted state, and it turns on pathways typically reserved for times of scarcity. (2010). They hold a patent on nicotinamide riboside production, and make Niagen. So a 10 mg serving of spermidine trihydrochloride will contain approximately 5 mg of pure spermidine. Professor David Sinclair is a Professor at Harvard University studying aging. 1 gram of spermidine in the morning. Theres little to no doubt in the research community that we need to restore NAD function; but the jury is still out on what the best method will be. He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School. 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