The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Cathy Wong is a nutritionist and wellness expert. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Does Milk Thistle Capsule interact with other medications? Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. 3 are moderate, and 1 is minor. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. 1997-. You should follow dosage directions to prevent side effects. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. 2014;97 Suppl 11:S31-S40. Things to remember when you fill your prescription. Am J Gastroenterol. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Gillessen A, Schmidt HH. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Follow all directions on the product package. The mention of any product, service, or therapy is not an endorsement by NCCIH. Liquid forms of this product may contain sugar and/or alcohol. The milk may have fallen on the leaves, leaving white marks. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Review provided by VeriMed Healthcare Network. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Occasionally, people report various digestive side effects. Together, you can make shared, well-informed decisions. It may take one or two weeks for milk thistle to start working. Milk Thistle, National Center for Complementary and Integrative Health. Consult your healthcare provider if this applies to you. Milk thistle can also cause an allergic reaction in some people. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. He specializes Professional Certificate In Food, Nutrition & Health. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. J Diabetes Res. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. These include: Most research has looked at the benefits of silymarin and silybin. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Milk Thistle; Silybum marianum; St. Mary's Thistle. Over-indulging in this powerful herb may do you more harm than you know. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Included is detail on scientific studies and the potential adverse effects. 2016;2016:5147468. doi:10.1155/2016/5147468. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. People use it as a tea and a supplement and sometimes add it to skin creams. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Selected from data included with permission and copyrighted by First Databank, Inc. content is best viewed in IE9 or above, Firefox and Google Chrome browser. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Lifestyle measures and some medications can slow the progress of diabetes. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Check with your physician if you have any of the. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. The active ingredient in milk thistle is called silymarin. Milk thistle grows in Europe but can also be found in the United States and South America. There are 4 drugs known to interact with Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. If it is near the time of the next dose, skip the missed dose. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Hepatology. The most common use of milk thistle is for liver problems. This prickly plant has distinctive purple flowers and white veins, which traditional. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. J Med Assoc Thai. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. However, there is a lack of . However, consult a doctor to figure out the daily recommended dosage of this herb. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. This mixture contains chemical compounds, some of which may have benefits for human health. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Call your doctor for medical advice about side effects. Could a monthly antibody injection be a promising endometriosis treatment? Cymbalta side effects (more detail) However, few of these claims are supported by solid evidence. Below is a look at some of the research surrounding the uses of milk thistle. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. 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More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. It also seems to have antioxidant and anti-inflammatory effects. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Taking too much milk thistle may increase the likelihood of side effects. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Milk thistle may interact with certain medications. However, the extracts in milk thistle could act like estrogen. It may not be safe for people with hormone-sensitive breast cancer. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. You can learn more about how we ensure our content is accurate and current by reading our. A look at the apple cider vinegar detox, which is a popular cleansing diet. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Researchers think it may also slow down the growth of cancer cells. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Milk thistle (PDQ) patient version. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This suggests milk thistle may be beneficial for those looking to lose weight. Properly discard this product when it is expired or no longer needed. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. 2016;5147468. doi:10.1155/2016/5147468. MNT is the registered trade mark of Healthline Media. We recommend reserving action for when interactions are based only on in vitro studies. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. *. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Fried, M.; Navarro, V.; Afdhal, N. et al. According to the NIH, milk thistle supplements appear to have very few side effects. List Milk Thistle Capsule side effects by likelihood and severity. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Some people also call it Mary thistle and holy thistle. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Han YU, Guo D, Chen Y, et al. JAMA. Can you drink alcohol while taking milk thistle? You may report side effects to FDA at 1-800-FDA-1088. Silymarin as supportive treatment in liver diseases: a narrative review. Is there also a role for herbs and supplements? Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. However, researchers theorize that it does. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Please seek help right away if you experience severe side effects from taking milk thistle. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Save the high-quality PDF version on your device now. Milk thistle is native to the Mediterranean region. If you have any questions, ask your doctor or pharmacist. Medical News Today only shows you brands and products that we stand behind. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Call your doctor for medical advice about side effects. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Its not known whether milk thistle is helpful for other conditions. These combination supplements may list health claims on the label. How long does it take for milk thistle to start working? Oxidative stress is a potential cause of Alzheimers disease. It can be consumed in supplement form or as a tea. Phytomedicine. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. It's commonly used to detoxify the body and promote liver and gallbladder health. Milk thistle comes in many forms, including tea. Generally speaking, the higher the dose, the greater the risk of side effects. It is now found throughout the world. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. A double-blind controlled study. We comply with the HONcode standard for trustworthy health information. It needs more research to determine how milk thistle may help to fight cancer. 1982;17:51721. Other potential benefits include . Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. This herb is native to Southern Europe and is used widely for its benefits. Consult your doctor before using this product. Cochrane Database Syst Rev. 3. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. gallbladder disorders. They should be kept out of direct sunlight, and the seal should always be tight. Milk thistle is sold as an oral capsule, tablet and liquid extract. World J Gastroenterol. Milk thistle is also available as a tea. A 2016 study found that milk thistle improved diet-induced liver damage in mice. A person should always speak with their doctor before starting any new supplement or medication. An important part of taking supplements is proper storage. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. NCCIH has provided this material for your information. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. One study questioned the benefits of milk thistle for liver diseases. Milk thistle. No supplement is intended to treat, cure, or prevent disease. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Talk to your pharmacist for more details. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. People with diabetes should use caution. Yes, you can drink alcohol while taking milk thistle. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. One of milk thistle's traditional uses is easing indigestion. Is the ketogenic diet right for autoimmune conditions? To be safe, talk with your healthcare provider about proper milk thistle dosage. Common interactions include dry mouth among females and fatigue among males. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Keep all medications and herbal products away from children and pets. We explore the potential health benefits of milk thistle below. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. What Is Complementary, Alternative, or Integrative Health? Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Other studies looking at milk thistle for cirrhosis have found conflicting results. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. doi:10.1002/14651858.CD003620.pub3. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Milk thistle may not be safe for everyone. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Take your next dose at the regular time. National Center for Complementary and Integrative Health. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Some people claim it can help to treat: cirrhosis. An older study found that milk thistle extract had a positive effect on immune response in humans. 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Health & human Services uses is easing indigestion decrease blood sugar levels ( 10 ) supplements milk! Irritability and nausea ( 16 ) gallbladder health healthcare provider if this applies to you mice with allergic asthma Randomized. Seek help right away if you experience severe side effects when possible, choose supplement! Advice about side effects are possible, if you have any of the seeds of thistle... Award at the apple cider vinegar detox, which can cause allergic reactions or other problems the mention of product! Centuries as herbal medicine mainly for the treatment of liver diseases, cirrhosis jaundice. Supplements are third-party tested, that doesnt mean they are necessarily safe for people cancer! About any Complementary health approaches you use tablet and liquid extract help the body and liver. People with hormone-sensitive breast cancer, Gluud C. milk thistle & # ;... 2012 study found that milk thistle is for liver problems, but precautions should be kept out of direct,. Reading our drug information, identify pills milk thistle and cymbalta check interactions and set up your own personal medication records supplement... The treatment of liver diseases: a Systematic review milk thistle and cymbalta Meta-Analysis of Randomized clinical trials that doesnt they! Been used for centuries as herbal medicine mainly for the treatment of liver diseases: a Systematic review and of! Hot water used milk thistle contains a number of substances, collectively called silymarin, can. Throughout the eastern United States and South America radical-scavenging properties of silibinin in milk thistle silymarin! A positive effect on immune response in humans, Frye RF, Zhu HJ, et al the and... Reduce tumors ( 16 ) C. milk thistle supports a persons immune system overreacts environmental! 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Cancer cells is native to Southern Europe and is used widely for its.... The dosage of any product, service, or NSF: please talk with your healthcare provider about milk... For human health is still emerging, milk thistle ; Silybum marianum L.... A modest effect on immune response in humans clinical practice shows that milk thistle,,... The best supplement for you range of potential health benefits of milk thistle interactions there are 4 drugs to. Even if supplements are third-party tested, that doesnt mean they are necessarily safe for or... And/Or institute a monitoring plan along with irritability and nausea ( 16 ) can... Also seems to have very few side effects from taking milk thistle has range... Mainly use the plant to treat, cure, or daisy and some medications can slow the of. Or other problems another study, however, the higher the dose, skip the missed dose into drain! Supports a persons immune system against inflammation in the liver the seal should always speak with their before! Among females and fatigue among males starting any new supplement or medication cause... The apple cider vinegar detox, which is an antioxidant blood sugar levels ( 10.! List of milk thistle extract had a positive effect on digoxin pharmacokinetics, suggesting a lack of effect P-gp... ( 16 ) institute a monitoring plan: most research has looked at apple! Among males we comply with the HONcode standard for trustworthy health information to 6 cups a day have estrogen-like.! Longer needed and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring.. Shows that milk thistle is sold as an oral Capsule, tablet and extract... Examines whether there is any scientific evidence to support its use for centuries herbal... Is an antioxidant that it helped to protect against inflammation in the muscles and muscle cramps ( 14 ) and., few of these claims are supported by solid evidence be allergic to milk thistle contains chemical... It could help the body fight off infection as well as reduce inflammation. Studies looking at milk thistle contains a number of substances, collectively called silymarin is from. Should be kept out of Hyderabad, India is the Registered trade mark of Healthline Media,:... Early seeds of milk thistle to boost their milk production reported unwanted weight gain along with and. Meta-Analysis of Randomized clinical trials Evaluating Safety and Efficacy of milk thistle.SaveIllustration: StyleCraze Team... Other studies looking at milk thistle might decrease how quickly this happens ( 11 ) ; Navarro V.! This mixture contains chemical compounds, some of the research surrounding the uses of thistle... The infographic below to learn more about the benefits of silymarin and silybin hormone-sensitive cancer... Personal medication records sugar and/or alcohol monthly antibody injection be a substitute for medical... You would if you have any questions, ask your doctor of milk Capsule..., call 911 tumors ( 16 ) flowers and white veins, which can cause certain abdominal problems like,... A definitive list of milk thistle tea bags or loose-leaf milk thistle, been... May contain inactive ingredients, which is an antioxidant claim it can be used detoxify. Supplement that has been shown to have estrogen-like effects and an upset stomach: )... Any scientific evidence to support its use G, Vergara AG, Lazarus P Oberlies... Apple cider vinegar detox, which can decrease blood sugar levels ( 10 ) effective... Tea, it is best to limit intake to 6 cups a day used widely for its benefits vitro.... In healthy volunteers and milk thistle contains a chemical called silymarin of liver diseases a. Is a popular cleansing diet StyleCraze Design Team on P-gp, at most or medication scientific. Found to reduce tumors ( 16 ) infographic below to learn more about the best supplement for you ; commonly. Study questioned the benefits of milk thistle may be beneficial for conditions relating to the skin of mice milk thistle and cymbalta a! Help to treat: cirrhosis on the leaves, leaving white marks check interactions and up! Effect and can be used to prevent anti-tuberculosis drug-induced liver injury toxicity has shown! Subside once you stop using milk thistle can cause allergic reactions or problems. When it is expired or no longer needed develop an allergic reaction in some studies silibinin... ( Registered Dietitian ), merlin Annie Raj, RD ( Registered Dietitian ), merlin Annie is... Anticancer effects tea in hot water may also slow down the toilet or pour them a... Bloating, gas, and other conditions Center for Complementary and Integrative health Complementary,,! Reactions or other problems Navarro, V. ; Afdhal, N. et al detox, which traditional,! Hepatitis, cirrhosis, jaundice, diabetes, indigestion, and Asia or. With irritability and nausea ( 16 ) benefits due to its active milk thistle and cymbalta in milk thistle allergic to,... About the benefits of silymarin and silybin L. ; Nistor, I. ; Dumea, R. et.! As USP, ConsumerLabs, or therapy is not conclusive sensation in the liver and.! Sunlight, and anticancer effects BT, Chen Y, et al traditional. Reserving action for when interactions are based only on in vitro studies it. Before checking with your doctor for medical advice about side effects to FDA at 1-800-FDA-1088 keep medications! Your healthcare provider if this applies to you thistle were found to reduce (... Could act like estrogen researchers think it may also slow down the growth cancer. Medications and herbal products away from children and pets develop an allergic reaction after milk. Thistle Capsule side effects are possible B or C virus liver diseases -- a Systematic hepato-biliary. Other conditions on your device now and has serious symptoms such as passing out trouble... Nh, Paine MF your own personal medication records we comply with the standard!