MR: The study was performed on human liver cells from one cell line cell cultures used for research purposes. Life need not ever end Depressing established scientific idea may be wrong, New interpretations of the laws of thermodynamics suggest the infamous heat death hypothesis which foretells the end of all life in the universe might not hold Read more , Italy passes law to clamp down on illegal migration, stop and fine NGO rescue ships Analysis, It takes courage to enforce rule of law Read more , PM Mitsotakis said a cross-party committee would investigate the train crash causes, Mitsotakis made an extraordinary statement on TV Read more , Author:Thema Newsroom | Published: March 2, 2022, , , . In the case of Covid shots, the vaccines from Moderna and Pfizer ( PFE )/BioNTech introduce a single spike protein. It is known from animal studies that it is also expressed early in embryonic development," explains Yang de Marinis. Coronaviruses, however, are not expected to do this, said Bethany Moore, chair of the University of Michigans Department of Microbiology and Immunology. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. Suggested accounts. Bad Bunny. This site needs JavaScript to work properly. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Pfizer didnt comment on the findings of the Swedish study and said only that its mRNA vaccine does not alter the human genome. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. The researchers write that the findings warrant a further More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose. In a lab environment, i.e., in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumor. It was assumed that the vaccines spike protein would remain mostly at the injection site and last up to several weeks like other proteins produced in the body. Based on this study, is there any reason to not get vaccinated? Would you like email updates of new search results? Indeed, if you look at the article in the journal in which it was published. As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. The approval came as an emergency use authorization on December 11, 2020, after clinical trials showed the vaccine was 95% effective in preventing COVID-19. The .gov means its official. It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. Salesforce has already slashed 8,000 workers from its ranks this year. It only presents the body with the instructions to build immunity.. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. doi: 10.1038/s41586-020-2639-4. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. The research was conducted at Lund University. 2020;586:589593. part may be reproduced without the written permission. See here for a complete list of exchanges and delays. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. 2022 Dec 7;44(4):72. doi: 10.1007/s40656-022-00548-1. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genomeand if so, if it has any consequences. Let's review the details of their method.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. 2022 Dec 9;14(12):e32361. doi: 10.1056/NEJMc2107717. time: 15 Cooks in: 1:40 Ready in: 1:55 Ingredients 1 kg beef flatiron 4 tbsp extra-virgin olive oil 1 garlic clove, finely chopped 1 tbsp tomato paste cup []. Comment on Aldn et al. DNA amplicons (444 bps) were visualized on agarose gel. J. Med. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. In the March 2022 issue of Parents PACK, we discussed some common misconceptions about science and scientists, and in the April 2022 issue, we discussed some surprising findings that were initially not believed but were ultimately proven to change our previously established understanding of science. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. Its Nature. The study has received a lot of media attention, what are your thoughts on that? In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. An official website of the United States government. YDM: The attention of the media and the general public reflects a concern among some regarding new vaccine technologies. Markus Aldn et al, Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, Current Issues in Molecular Biology (2022). BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. Materials in this section are updated as new information and vaccines become available. Bad Bunny. Evaluating information: What you should know, Dissecting social media: What you should know. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more These cells have had the normal protections of the immune system removed.. DNA, contained in all cells, is the building block of the bodys genetic code. Getty Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. Montoya JG, Adams AE, Bonetti V, Deng S, Link NA, Pertsch S, Olson K, Li M, Dillon EC, Frosch DL. 2022 Feb 28;194(8):E297-E305. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 41.2M. This paper compared protein sequences from the SARS-CoV-2 virus to protein sequences in humans and described where the latter are found in the body. National Library of Medicine A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. Unauthorized use of these marks is strictly prohibited. Finally, only looking at figure 1 dismisses the other data in the paper, such as the fact that people who were vaccinated were more likely to be asymptomatic and unvaccinated people tended to be more severely ill compared with vaccinated people. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. Pfizer Vaccine Becomes DNA in Liver Cells. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. 5. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. Current Issues in Molecular Biology. Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient. This genetic material contains instructions the body's cells use to build a protein found in a bacterium or virus, and that protein is then recognized by the immune system. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. badbunny. RNA levels of BNT162b2 are presented as logged 2, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. This is part of APs effort to address widely shared misinformation, including work with outside companies and organizations to add factual context to misleading content that is circulating online. ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. Front Immunol. badbunny. This is part of APs effort to address widely shared misinformation, including work with outside companies and organizations to add factual context to misleading content that is circulating online. This three-part series was aimed at describing several important aspects of science. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). Likewise, the Results section has five sentences. Genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA pfizer vaccine becomes dna in liver unique BNT162b2! 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